An ectopic pregnancy is a potentially life-threatening medical emergency that can result in infertility. Symptoms are not easy to identify, but are often accompanied by bleeding which could be due to unrelated factors.
The risk of death during ectopic pregnancy is higher than it is for a normal pregnancy, with the risk increasing as the number of weeks passed approaches 10. By the time your second sign occurs, there’s a 50/50 chance that you’re experiencing an ectopic pregnancy, which means you should seek medical treatment without delay!
Risk Factors
Risk factors include previous history of ectopic pregnancy- if pregnancy occurs outside of uterus or tube. You are more at risk if you have had pelvic inflammatory disease or have experienced fertility problems. Male sterilisation via vasectomy is also risk factor. If there is a genetic factor you could risk being passed on to your future children, as there are a host of genetic issues which can cause ectopic pregnancy. Other factors include having had a prior salpingectomy for ectopic pregnancy, radiation, high altitude and high hormone levels.

HOW DOES HISTAMINE PROTECT AGAINST ECTOPIC PREGNANCY?

Histamine is a naturally-occurring bi-product in the body, which is produced through a conversion of nitrogen via anaerobic bacterial cell metabolism. Histamine levels can have an effect on the developing baby during gestation and this hormone is released in blood by immune cells, the nervous system, gastrointestinal tract, and vascular smooth muscles. Histamine acts to stimulate blood vessels, as well as increase bronchodilation and play a part in lowering gastric acid secretion. Histamine also regulates the blood pressure and is regarded as a neurotransmitter. Pregnancy can cause a surge in the amount of histamine present in the body, leading to a rise in concentration and distribution. Research has shown that histamine has an important role in maintaining ectopic pregnancy stability by promoting smooth muscle cell proliferation, inducing cell differentiation, and regulating endometrial tissue preparation.

HOW DOES HISTAMINE PROTECT AGAINST ECTOPIC PREGNANCY?

Histamine has been shown to have the ability to counteract the overproduction of factors which play a part in ectopic pregnancy, making it a good candidate for treatment. Histamine has been shown to have the ability to counter inflammation, uterine contractions, and vascular function. Histamine-releasing compounds, such as the compound 5-hydroxydopamine, were shown to inhibit ectopic pregnancy when injected into the fallopian tubes. Histamine itself was shown to inhibit the growth of the fertilised egg and decrease the number of released implantations when orally dissolved. More recently, histamine was shown to protect a developing embryo of ectopic pregnancy by causing DNA damage in the fertilised egg, resulting in an arrest of development. Histamine also has the ability to regulate the growth and death of tissues and potentially inhibit the growth of ectopic pregnancy, which is a cause of ectopic pregnancy. Histamine has also been shown to reduce uterine contractility and the uterine contraction frequency within 24-48 hours of ovulation, which shows that it may be used during pregnancy to regulate the stability of pregnancy.

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